Funded by the National Institute of General Medical Sciences at the NIH and housed at the University of Pittsburgh National Center of Excellence, MIDAS is a collaborative network of research scientists who use computational, statistical, and mathematical models to understand infectious disease dynamics and thereby assist the nation to prepare for, detect, and respond to infectious disease threats. This project has supported a variety of work, including predictions of the impact of a new dengue vaccine in populations with different immunological backgrounds and point-pattern analysis of the 1918 influenza pandemic within the city of Chicago.