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  • Fluscape

Fluscape

Fluscape

Immune Landscapes of Human Influenza in Households, Towns, and Cities in Southern China

The goal of Fluscape is to characterize the immunological profiles to human influenza in space and time of individuals residing in the Guangzhou Province, China, and to capture the transmission dynamics contributing to those observed immunological distributions through computational models.  

The influenza virus is one of the most genetically mutable pathogens of humans. Our immune response places substantial pressure on the virus, resulting in rapid turnover of genetic lineages from year to year while building a record of the strains we have been infected with in the form of strain-specific antibodies. These patterns of these immunological profiles in space and time present a rich data source for investigation of the impact of human social interactions and demographics on influenza transmission, key determinants of the ecology of the influenza virus. In this ongoing study, researchers from several institutions in the US, the UK, Hong Kong, and China will conduct a study of the immune landscape of influenza, linking that immune landscape, at the individual-level, to data on household structure, travel behavior and social networks. 

Aging, a project under Fluscape, aims to analyze influenza dynamics in southern China in relation to specific household demographics, social networks, and immune response. These data will be collected via a spatially structured sample regime of randomly selected houses in the study space, contact diaries from these individuals, and sera collection for antibody tests. After data collection, a spatially explicit dynamic demographic model of the population of Guangdong and influenza transmission models will be used to test specific hypotheses concerning the relationship between population density, travel behavior, household structure and non-household social networks on disease incidence.

Principal Investigator

Derek Cummings Professor
Justin Lessler Associate Professor, JHSPH
Steven Riley Professor, ICL

Funders

NIH Ecology of Infectious Disease Program
National Institute on Aging
Wellcome Trust

Collaborators

Guangzhou Hospital No. 12
Hong Kong University
University of Liverpool
Imperial College London
Johns Hopkins Bloomberg School of Public Health

Publications

Cohort Profile: A study of influenza immunity in the urban and rural Guangzhou region of China: the Fluscape Study.
Jiang CQ, Lessler J, Kim L, Kwok KO, Read JM, Wang S, Tan L, Hast M, Zhu H, Guan Y, Riley S, Cummings DA.
Int J Epidemiol, 2016: 10.1093/ije/dyv353
Estimating the life course of influenza AH3N2 antibody responses from cross-sectional data.
Kucharski AJ, Lessler J, Read JM, Zhu H, Jiang CQ, Guan Y, Cummings DA, Riley S.
PLoS Biol, 2015: 13: e1002082, 10.1371/journal.pbio.1002082
Social contacts and the locations in which they occur as risk factors for influenza infection.
Kwok KO, Cowling BJ, Wei VW, Wu KM, Read JM, Lessler J, Cummings DA, Peiris JS, Riley S.
Proc Biol Sci, 2014: 281: 20140709, 10.1098/rspb.2014.0709
Social mixing patterns in rural and urban areas of southern China.
Read JM, Lessler J, Riley S, Wang S, Tan LJ, Kwok KO, Guan Y, Jiang CQ, Cummings DA.
Proc Biol Sci, 2014: 281: 20140268, 10.1098/rspb.2014.0268
Evidence for antigenic seniority in influenza A H3N2 antibody responses in southern China.
Lessler J, Riley S, Read JM, Wang S, Zhu H, Smith GJ, Guan Y, Jiang CQ, Cummings DA.
PLoS Pathog, 2012: 8: e1002802, 10.1371/journal.ppat.1002802
Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China.
Lessler J, Cummings DA, Read JM, Wang S, Zhu H, Smith GJ, Guan Y, Jiang CQ, Riley S.
Nat Commun, 2011: 2: 423, 10.1038/ncomms1432

Contact

Tel: +1 352-273-6555

Email: info [at] ufiddynamics.org

Infectious Disease Dynamics Group
c/o Derek Cummings
University of Florida
Department of Biology
P.O. Box 118525
Gainesville, FL 32611

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